GeneGeneInteR vignette Introduction
نویسندگان
چکیده
The package GeneGeneInteR aims at providing a collection of statistical methods to search for interaction between genes in case-control association studies. These methods are dedicated to the analysis of biallelic SNPs (Single Nucleotide Polymorphism) genotype data. This vignette describes the complete analysis pipeline of a set of k > 2 genes, going from data importation to results visualization via data manipulation and statistical analysis.
منابع مشابه
Genegeneinter Vignette Statistical Analysis of the Interaction between a Pair of Genes
Let consider a sample of n individuals with nc controls and nd cases (nc+nd = n) and Y = [y1, . . . , yn] ′ the vector of the observed binary phenotypes. Each gene is a collection of respectively m1 and m2 SNPs. The observed genotypes for gene X1 can be represented by a n×m1 matrix: X1 = [xij ]i∈1...n;j∈1...m1 where xij ∈ {0; 1; 2} is the number of copies of the minor allele for SNP j carried b...
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